Enteric, pH sensitive GARs

1: What are Bright-GAR Capsules

GAR stands for Gastric Acid Resistant capsules.
Bright-GAR capsules are HPMC based and coated with 1 of 3 different pH sensitive enteric coating polymer system: HPMC-AS, methacrylate or HPMCP. Bright-GARs are designed primarily for the purpose of delivering live microbes, enzymes, and acid sensitive ingredients such as bio-pharma cancer APIs to safely pass through stomach gastric acid and release contents quickly in upper intestine where pH changes from acidity to neutral.

2: Delivery locations of 3 types of Bright-GAR

We make 3 types of GAR capsules for different location - delivery in the upper intestine:

1) Bright GAR-AS capsules: HMPCAS are coated on our regular HPMC capsules to form Bright-GAR-AS that are compliant to FDA pharmaceutical and nutritional industry requirements. HPMCAS also have higher pH range sensitivity, therefore, good for delivery to Duodeno regions of small intestine.

2) Bright GAR-MA capsules: Methacrylate copolymers are coated on Goh-Veg HPMC capsules to form Bright GAR-MA capsules that are compliant to EFSA nutritional industry requirements.

3) Bright GAR-PH capsules: Based on Goh-Veg HPMC capsules, using HPMCP as coating materials that are compliant to UPS, EP, JP and IP requirements. HPMCP also has lower pH range sensitivity, therefore, good for delivery to Duodenum area of small intestine.

3: How Bright-GAR capsules are superior

Tests performed in USP simulated gastric fluid show that Bright GAR HPMC capsules can withstand up to 3 hours in human stomach, yet will fully release its content 6 minutes into the intestine environment. Comparing with other DR (delayed release) capsules currently in the market, our GAR HPMC capsules are superior in the following ways:

1) pH sensitive release
Bright-GAR capsules only rupture and release contents when surrounding pH changes from acid to neutral.

2) Upper intestine delivery
The long intact time of Bright-GAR capsules in gastric acid assures release of contents in designed location: upper intestine.

3) Easy to use
Snap close like regular capsules and no further sealing or banding is needed for Bright-GAR due to our capsule's unique closing system.

4) Enhanced machine-ability
Bright-GAR are stronger and run better on automatic encapsulation machines.

5) Economical
Save costs by eliminate after-fill coating that requires investments on building, machine and labor forces.

4: Size, color and printing

Following sizes are made regularly and kept in stock:
00#, 0#, 1# and 2#
Other size are available by custom order.
Color and printing options are available, customers can choose any color or printing of their liking, as long as there are such pigments and inks that are commercially available.

Please contact us for more details.